cGMP Analogues with Opposing Actions on CNG Channels Selectively Modulate Rod or Cone Photoreceptor Function

• Main Authors: Sophie Wucherpfennig (Author), Wadood Haq (Author), Valerie Popp (Author), Sandeep Kesh (Author), Soumyaparna Das (Author), Christian Melle (Author), Andreas Rentsch (Author), Frank Schwede (Author), François Paquet-Durand (Author), Vasilica Nache (Author)
• Format: Book
• Published: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The vertebrate retina harbors rod and cone photoreceptors. Human vision critically depends on cone photoreceptor function. In the phototransduction cascade, cGMP activates distinct rod and cone isoforms of the cyclic nucleotide-gated (CNG) channel. Excessive cGMP levels initiate a pathophysiological...