Pathological prolongation of action potential duration as a cause of the reduced alpha-adrenoceptor-mediated negative inotropy in streptozotocin-induced diabetic mice myocardium

• Main Authors: Haruna Kanae (Author), Shogo Hamaguchi (Author), Yumi Wakasugi (Author), Taichi Kusakabe (Author), Keisuke Kato (Author), Iyuki Namekata (Author), Hikaru Tanaka (Author)
• Format: Book
• Published: Elsevier, 2017-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Effect of pathological prolongation of action potential duration on the α-adrenoceptor-mediated negative inotropy was studied in streptozotocin-induced diabetic mice myocardium. In streptozotocin-treated mouse ventricular myocardium, which had longer duration of action potential than that in control...