Phosphoenolpyruvate carboxykinase 2-mediated metabolism promotes lung tumorigenesis by inhibiting mitochondrial-associated apoptotic cell death

• Main Authors: Jing Zhang (Author), Wenjuan He (Author), Dongmei Liu (Author), Wenyu Zhang (Author), Huan Qin (Author), Song Zhang (Author), Ailan Cheng (Author), Qiang Li (Author), Feilong Wang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BackgroundIt is unknown how cancer cells override apoptosis and maintain progression under nutrition-deprived conditions within the tumor microenvironment. Phosphoenolpyruvate carboxykinase (PEPCK or PCK) catalyzes the first rate-limiting reaction in gluconeogenesis, which is an essential metabolic...