Phosphoenolpyruvate carboxykinase 2-mediated metabolism promotes lung tumorigenesis by inhibiting mitochondrial-associated apoptotic cell death

• 主要な著者: Jing Zhang (著者), Wenjuan He (著者), Dongmei Liu (著者), Wenyu Zhang (著者), Huan Qin (著者), Song Zhang (著者), Ailan Cheng (著者), Qiang Li (著者), Feilong Wang (著者)
• フォーマット: 図書
• 出版事項: Frontiers Media S.A., 2024-08-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

BackgroundIt is unknown how cancer cells override apoptosis and maintain progression under nutrition-deprived conditions within the tumor microenvironment. Phosphoenolpyruvate carboxykinase (PEPCK or PCK) catalyzes the first rate-limiting reaction in gluconeogenesis, which is an essential metabolic...