Roles of small GTPase Rac1 in the regulation of actin cytoskeleton during dengue virus infection.

• Main Authors: Jia-Li Wang (Author), Jun-Lei Zhang (Author), Wei Chen (Author), Xiao-Feng Xu (Author), Na Gao (Author), Dong-Ying Fan (Author), Jing An (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: Increased vascular permeability is a hallmark feature in severe dengue virus (DV) infection, and dysfunction of endothelial cells has been speculated to contribute in the pathogenesis of dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). Rho-family GTPase Rac1 is a significant ele...