Development and validation of an HPLC-MS/MS method to determine clopidogrel in human plasma

• Autors principals: Gangyi Liu (Autor), Chunxia Dong (Autor), Weiwei Shen (Autor), Xiaopei Lu (Autor), Mengqi Zhang (Autor), Yuzhou Gui (Autor), Qinyi Zhou (Autor), Chen Yu (Autor)
• Format: Llibre
• Publicat: Elsevier, 2016-01-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

A quantitative method for clopidogrel using online-SPE tandem LC-MS/MS was developed and fully validated according to the well-established FDA guidelines. The method achieves adequate sensitivity for pharmacokinetic studies, with lower limit of quantifications (LLOQs) as low as 10 pg/mL. Chromatogra...