Development and validation of an HPLC-MS/MS method to determine clopidogrel in human plasma

• Main Authors: Gangyi Liu (Author), Chunxia Dong (Author), Weiwei Shen (Author), Xiaopei Lu (Author), Mengqi Zhang (Author), Yuzhou Gui (Author), Qinyi Zhou (Author), Chen Yu (Author)
• Format: Book
• Published: Elsevier, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A quantitative method for clopidogrel using online-SPE tandem LC-MS/MS was developed and fully validated according to the well-established FDA guidelines. The method achieves adequate sensitivity for pharmacokinetic studies, with lower limit of quantifications (LLOQs) as low as 10 pg/mL. Chromatogra...