A phase I trial assessing the safety, pharmacokinetics, cerebrospinal fluid penetrance, and food effect of BTK inhibitor tolebrutinib in healthy volunteers

A phase I trial assessing the safety, pharmacokinetics, cerebrospinal fluid penetrance, and food effect of BTK inhibitor tolebrutinib in healthy volunteers

Abstract Tolebrutinib is an oral, brain‐penetrant, covalent Bruton's tyrosine kinase inhibitor in development to treat multiple sclerosis at 60 mg/day with food. A phase I trial was conducted in healthy volunteers to assess the safety and pharmacokinetics of tolebrutinib at oral doses higher th...

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Main Authors: Marie‐José Cabanis (Author), Olivier Nicolas (Author), Olivier Vitse (Author), Christelle Jan (Author), Priscilla Brun (Author), Patrick Soubayrol (Author), William B. Smith (Author), Timothy J. Turner (Author), Emmanuel Krupka (Author)
Format: Book
Published: Wiley, 2024-02-01T00:00:00Z.
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