Comprehensive behavioral analysis and quantification of brain free amino acids of C57BL/6J congenic mice carrying the 1473G allele in tryptophan hydroxylase‐2

Comprehensive behavioral analysis and quantification of brain free amino acids of C57BL/6J congenic mice carrying the 1473G allele in tryptophan hydroxylase‐2

Abstract Aim Tryptophan hydroxylase 2 (Tph2) is a rate‐limiting enzyme for the biosynthesis of 5‐hydroxytryptamine (5‐HT, serotonin). Previous studies have reported that C1473G polymorphism of the murine Tph2 gene leads to decreased 5‐HT levels in the brain and abnormal behavioral phenotypes, such a...

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Main Authors: Hisatsugu Koshimizu (Author), Nao Hirata (Author), Keizo Takao (Author), Keiko Toyama (Author), Takashi Ichinose (Author), Shigeki Furuya (Author), Tsuyoshi Miyakawa (Author)
Format: Book
Published: Wiley, 2019-03-01T00:00:00Z.
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