Uniform sarcolemmal dystrophin expression is required to prevent extracellular microRNA release and improve dystrophic pathology

• Main Authors: Tirsa L.E. vanWestering (Author), Yulia Lomonosova (Author), Anna M.L. Coenen‐Stass (Author), Corinne A. Betts (Author), Amarjit Bhomra (Author), Margriet Hulsker (Author), Lucy E. Clark (Author), Graham McClorey (Author), Annemieke Aartsma‐Rus (Author), Maaike vanPutten (Author), Matthew J.A. Wood (Author), Thomas C. Roberts (Author)
• Format: Book
• Published: Wiley, 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Duchenne muscular dystrophy (DMD) is a fatal muscle‐wasting disorder caused by genetic loss of dystrophin protein. Extracellular microRNAs (ex‐miRNAs) are putative, minimally invasive biomarkers of DMD. Specific ex‐miRNAs (e.g. miR‐1, miR‐133a, miR‐206, and miR‐483) are highly up...