Investigation of Crystallization and Salt Formation of Poorly Water-Soluble Telmisartan for Enhanced Solubility

• Main Authors: Chulhun Park (Author), Nileshkumar M. Meghani (Author), Yongkwan Shin (Author), Euichaul Oh (Author), Jun-Bom Park (Author), Jing-Hao Cui (Author), Qing-Ri Cao (Author), Thao Truong-Dinh Tran (Author), Phuong Ha-Lien Tran (Author), Beom-Jin Lee (Author)
• Format: Book
• Published: MDPI AG, 2019-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The crystal changes and salt formation of poorly water-soluble telmisartan (TEL) in various solvents were investigated for enhanced solubility, stability and crystallinity. Polymorphic behaviors of TEL were characterized by dispersing in distilled water, acetone, acetonitrile, DMSO, or ethanol using...