Pharmacologic Activities¬ of 3'-Hydroxypterostilbene: Cytotoxic, Anti-Oxidant, Anti-Adipogenic, Anti-Inflammatory, Histone Deacetylase and Sirtuin 1 Inhibitory Activity
Purpose: Delineate the selected pharmacodynamics of a naturally occurring stilbene 3'-Hydroxypterostilbene. Objective: Characterize for the first time the pharmacodynamics bioactivity in several in-vitro assays with relevant roles in heart disease, inflammation, cancer, and diabetes etiology an...
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| Main Authors: | , , |
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| Format: | Book |
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Frontiers Media S.A.,
2015-11-01T00:00:00Z.
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| Summary: | Purpose: Delineate the selected pharmacodynamics of a naturally occurring stilbene 3'-Hydroxypterostilbene. Objective: Characterize for the first time the pharmacodynamics bioactivity in several in-vitro assays with relevant roles in heart disease, inflammation, cancer, and diabetes etiology and pathophysiology. Methods: 3'-Hydroxypterostilbene was studied in in-vitro assays to identify possible bioactivity. Results: 3'-Hydroxypterostilbene demonstrated anti-oxidant, anti-inflammatory, cytotoxic, anti-adipogenic, histone deacetylase, and sirtuin-1 inhibitory activity. Conclusions: The importance of understanding individual stilbene pharmacologic activities were delineated. Small changes in chemical structure of stilbene compounds result in significant pharmacodynamic differences. This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page. |
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| Item Description: | 10.18433/J33W4C 1482-1826 |