Structure-function relationship of dynorphin B variants using naturally occurring amino acid substitutions

• 主要な著者: Luca Zangrandi (著者), Barbara Fogli (著者), Anna Mutti (著者), René Staritzbichler (著者), Victoria Most (著者), Peter W. Hildebrand (著者), Regine Heilbronn (著者), Christoph Schwarzer (著者)
• フォーマット: 図書
• 出版事項: Frontiers Media S.A., 2024-10-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Dynorphins (Dyn) represent the subset of endogenous opioid peptides with the highest binding affinity to kappa opioid receptors (KOPrs). Activation of the G-protein-coupled pathway of KOPrs has strong anticonvulsant effects. Dyn also bind to mu (MOPrs) and delta opioid receptors (DOPrs) with lower a...