Structure-function relationship of dynorphin B variants using naturally occurring amino acid substitutions

• Main Authors: Luca Zangrandi (Author), Barbara Fogli (Author), Anna Mutti (Author), René Staritzbichler (Author), Victoria Most (Author), Peter W. Hildebrand (Author), Regine Heilbronn (Author), Christoph Schwarzer (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dynorphins (Dyn) represent the subset of endogenous opioid peptides with the highest binding affinity to kappa opioid receptors (KOPrs). Activation of the G-protein-coupled pathway of KOPrs has strong anticonvulsant effects. Dyn also bind to mu (MOPrs) and delta opioid receptors (DOPrs) with lower a...