Mining the Synergistic Core Allosteric Modules Variation and Sequencing Pharmacological Module Drivers in a Preclinical Model of Ischemia

• Main Authors: Yingying Zhang (Author), Zide Zhao (Author), Yanan Yu (Author), Jun Liu (Author), Pengqian Wang (Author), Bing Li (Author), Xiaoxu Zhang (Author), Yinying Chen (Author), Zhong Wang (Author)
• Format: Book
• Published: Wiley, 2018-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Identifying the variation of core modules and hubs seems to be critical for characterizing variable pharmacological mechanisms based on topological alteration of disease networks. We first identified a total of eight core modules by using an approach of multiple modular characteristic fusing (MMCF)...