Method development and validation of Guanfacine in rat plasma by liquid chromatographyâtandem mass spectrometry: Application to a pharmacokinetic study

• Main Authors: Suryanarayana Murthy Goparaju (Author), Yadagiri Srinivasa Murthy Nandula (Author), Chandrasekher Bannoth Kothapalli (Author), B.R. Challa (Author), Bahlul Z. Awen (Author)
• Format: Book
• Published: Elsevier, 2013-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A selective, sensitive and high-throughput liquid chromatographyâtandem mass spectrometry (LCâESI-MS/MS) method has been developed and validated for the quantitation of Guanfacine in rat plasma. Sample clean-up involved liquidâliquid extraction (LLE) and 100 μL of rat plasma was used. YMC BASIC co...