Instability of aquaglyceroporin (AQP) 2 contributes to drug resistance in Trypanosoma brucei.

• Hauptverfasser: Juan F Quintana (VerfasserIn), Juan Bueren-Calabuig (VerfasserIn), Fabio Zuccotto (VerfasserIn), Harry P de Koning (VerfasserIn), David Horn (VerfasserIn), Mark C Field (VerfasserIn)
• Format: Buch
• Veröffentlicht: Public Library of Science (PLoS), 2020-07-01T00:00:00Z.
• Schlagworte: article
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Defining mode of action is vital for both developing new drugs and predicting potential resistance mechanisms. Sensitivity of African trypanosomes to pentamidine and melarsoprol is predominantly mediated by aquaglyceroporin 2 (TbAQP2), a channel associated with water/glycerol transport. TbAQP2 is ex...