Dissolution Enhancement in Cocoa Extract, Combining Hydrophilic Polymers through Hot-Melt Extrusion

• Main Authors: Ludmila A. G. Pinho (Author), Saulo G. Souza (Author), Ricardo N. Marreto (Author), Livia L. Sa-Barreto (Author), Tais Gratieri (Author), Guilherme M. Gelfuso (Author), Marcilio Cunha-Filho (Author)
• פורמט: ספר
• יצא לאור: MDPI AG, 2018-08-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

The aim of this study was to improve the physicochemical properties of cocoa extract (CE) using hot-melt extrusion (HME) for pharmaceutical proposes. A mixture design was applied using three distinct hydrophilic polymeric matrices (Soluplus, Plasdone S630, and Eudragit E). Systems obtained by HME we...