Dabigatran Acylglucuronide, the Major Metabolite of Dabigatran, Shows a Weaker Anticoagulant Effect than Dabigatran

• Main Authors: Jong-Min Kim (Author), Jihyeon Noh (Author), Jin-Woo Park (Author), Hyewon Chung (Author), Kyoung-Ah Kim (Author), Seung Bin Park (Author), Jun-Seok Lee (Author), Ji-Young Park (Author)
• Format: Book
• Published: MDPI AG, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dabigatran (DAB) is an orally administered thrombin inhibitor. Both DAB and its main metabolite dabigatran acylglucuronide (DABG) have established anticoagulant effects. Here, we aimed to compare the relative anticoagulant effects of DABG and DAB in humans. Anticoagulant effects of DAB and DABG were...