Modeling Melanoma Heterogeneity In Vitro: Redox, Resistance and Pigmentation Profiles

• Main Authors: Larissa Anastacio da Costa Carvalho (Author), Isabella Harumi Yonehara Noma (Author), Adriana Hiromi Uehara (Author), Ádamo Davi Diógenes Siena (Author), Luciana Harumi Osaki (Author), Mateus Prates Mori (Author), Nadja Cristhina de Souza Pinto (Author), Vanessa Morais Freitas (Author), Wilson Araújo Silva Junior (Author), Keiran S. M. Smalley (Author), Silvya Stuchi Maria-Engler (Author)
• Format: Book
• Published: MDPI AG, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Microenvironment and transcriptional plasticity generate subpopulations within the tumor, and the use of BRAF inhibitors (BRAFis) contributes to the rise and selection of resistant clones. We stochastically isolated subpopulations (C1, C2, and C3) from naïve melanoma and found that the clones demons...