Temozolomide and oral etoposide in children with recurrent malignant brain tumors

• Main Authors: Antonio Ruggiero (Author), Anna Ariano (Author), Silvia Triarico (Author), Michele Antonio Capozza (Author), Alberto Romano (Author), Palma Maurizi (Author), Stefano Mastrangelo (Author), Giorgio Attinà (Author)
• Format: Book
• Published: BioExcel Publishing Ltd, 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Despite advances in the treatment of brain tumors, the prognosis of children with recurrent malignant brain tumors remains poor. Etoposide (VP-16), an inhibitor of nuclear enzyme deoxyribonucleic acid (DNA)-topoisomerase II, has shown activity in brain tumors. Its efficacy appears schedule dependent...