Cytidine-containing tails robustly enhance and prolong protein production of synthetic mRNA in cell and in vivo

• Main Authors: Cheuk Yin Li (Author), Zhenghua Liang (Author), Yaxin Hu (Author), Hongxia Zhang (Author), Kharis Daniel Setiasabda (Author), Jiawei Li (Author), Shaohua Ma (Author), Xiaojun Xia (Author), Yi Kuang (Author)
• Format: Book
• Published: Elsevier, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Synthetic mRNAs are rising rapidly as alternative therapeutic agents for delivery of proteins. However, the practical use of synthetic mRNAs has been restricted by their low cellular stability as well as poor protein production efficiency. The key roles of poly(A) tail on mRNA biology inspire us to...