The Selective SIK2 Inhibitor ARN-3236 Produces Strong Antidepressant-Like Efficacy in Mice via the Hippocampal CRTC1-CREB-BDNF Pathway

• Main Authors: Yue Liu (Author), Wenqian Tang (Author), Chunhui Ji (Author), Jianghong Gu (Author), Yanmei Chen (Author), Jie Huang (Author), Xinyi Zhao (Author), Yingfang Sun (Author), Chengniu Wang (Author), Wei Guan (Author), Jianfeng Liu (Author), Bo Jiang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Depression is a widespread chronic medical illness affecting thoughts, mood, and physical health. However, the limited and delayed therapeutic efficacy of monoaminergic drugs has led to intensive research efforts to develop novel antidepressants. ARN-3236 is the first potent and selective inhibitor...