RNA-seq analysis reveals significant transcriptome changes in huntingtin-null human neuroblastoma cells

Abstract Background Huntingtin (Htt) protein is the product of the gene mutated in Huntington's disease (HD), a fatal, autosomal dominant, neurodegenerative disorder. Normal Htt is essential for early embryogenesis and the development of the central nervous system. However, the role of Htt in a...

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Main Authors: Johanna Bensalel (Author), Hongyuan Xu (Author), Michael L. Lu (Author), Enrico Capobianco (Author), Jianning Wei (Author)
Format: Book
Published: BMC, 2021-07-01T00:00:00Z.
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