RNA-seq analysis reveals significant transcriptome changes in huntingtin-null human neuroblastoma cells

• Үндсэн зохиолчид: Johanna Bensalel (Зохиогч), Hongyuan Xu (Зохиогч), Michael L. Lu (Зохиогч), Enrico Capobianco (Зохиогч), Jianning Wei (Зохиогч)
• Формат: Ном
• Хэвлэсэн: BMC, 2021-07-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Abstract Background Huntingtin (Htt) protein is the product of the gene mutated in Huntington's disease (HD), a fatal, autosomal dominant, neurodegenerative disorder. Normal Htt is essential for early embryogenesis and the development of the central nervous system. However, the role of Htt in a...