RNA-seq analysis reveals significant transcriptome changes in huntingtin-null human neuroblastoma cells

• Main Authors: Johanna Bensalel (Author), Hongyuan Xu (Author), Michael L. Lu (Author), Enrico Capobianco (Author), Jianning Wei (Author)
• Format: Book
• Published: BMC, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Huntingtin (Htt) protein is the product of the gene mutated in Huntington's disease (HD), a fatal, autosomal dominant, neurodegenerative disorder. Normal Htt is essential for early embryogenesis and the development of the central nervous system. However, the role of Htt in a...