From genomic spectrum of NTRK genes to adverse effects of its inhibitors, a comprehensive genome-based and real-world pharmacovigilance analysis

• Main Authors: Zhiwei Cui (Author), Zhen Zhai (Author), De Xie (Author), Lihui Wang (Author), Feiyan Cheng (Author), Siyu Lou (Author), Fan Zou (Author), Rumeng Pan (Author), Shixue Chang (Author), Haoyan Yao (Author), Jing She (Author), Yidan Zhang (Author), Xinyuan Yang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: The discovery of neurotrophic tyrosine receptor kinase (NTRK) gene fusions has facilitated the development of precision oncology. Two first-generation NTRK inhibitors (larotrectinib and entrectinib) are currently approved for the treatment of patients with solid tumors harboring NTRK g...