Effects of Comedication and Genetic Factors on the Population Pharmacokinetics of Lamotrigine: A Prospective Analysis in Chinese Patients With Epilepsy

• Main Authors: Zhan-zhang Wang (Author), Yue-feng Zhang (Author), Wen-can Huang (Author), Xi-pei Wang (Author), Xiao-jiao Ni (Author), Hao-yang Lu (Author), Jin-qing Hu (Author), Shu-hua Deng (Author), Xiu-qing Zhu (Author), Huan-shan Xie (Author), Hong-zhen Chen (Author), Ming Zhang (Author), Chang Qiu (Author), Yu-guan Wen (Author), De-wei Shang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Lamotrigine (LTG) is a second-generation anti-epileptic drug widely used for focal and generalized seizures in adults and children, and as a first-line medication in pregnant women and women of childbearing age. However, LTG pharmacokinetics shows high inter-individual variability, thus potentially...