Melatonin derivative 6a as a PARP-1 inhibitor for the treatment of Parkinson's disease

• 主要な著者: Qing-Wei Ma (著者), Rui-Ting Han (著者), Zi-Jie Wu (著者), Jun-Jie Zhou (著者), Meng-Ting Chen (著者), Xiang-Zhi Zhang (著者), Wen-Zhe Ma (著者), Na Feng (著者)
• フォーマット: 図書
• 出版事項: Frontiers Media S.A., 2024-02-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Both continuous oxidative stress and poly (ADP-ribose) polymerase 1 (PARP-1) activation occur in neurodegenerative diseases such as Parkinson's disease. PARP-1 inhibition can reverse mitochondrial damage and has a neuroprotective effect. In a previous study, we synthesized melatonin derivative...