Platelets are highly efficient and efficacious carriers for tumor-targeted nano-drug delivery

• Main Authors: Qi-Rui Li (Author), Hua-Zhen Xu (Author), Rong-Cheng Xiao (Author), Yan Liu (Author), Jun-Ming Tang (Author), Jian Li (Author), Ting-Ting Yu (Author), Bin Liu (Author), Liu-Gen Li (Author), Mei-Fang Wang (Author), Ning Han (Author), Yong-Hong Xu (Author), Chao Wang (Author), Naoki Komatsu (Author), Li Zhao (Author), Xing-Chun Peng (Author), Tong-Fei Li (Author), Xiao Chen (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The present work aims to prove the concept of tumor-targeted drug delivery mediated by platelets. Doxorubicin (DOX) attached to nanodiamonds (ND-DOX) was investigated as the model payload drug of platelets. In vitro experiments first showed that ND-DOX could be loaded in mouse platelets in a dose-de...