The Circadian Hormone Melatonin Inhibits Morphine-Induced Tolerance and Inflammation via the Activation of Antioxidative Enzymes

• Prif Awduron: Ing-Jung Chen (Awdur), Chih-Ping Yang (Awdur), Sheng-Hsiung Lin (Awdur), Chang-Mei Lai (Awdur), Chih-Shung Wong (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: MDPI AG, 2020-08-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Opioids are commonly prescribed for clinical pain management; however, dose-escalation, tolerance, dependence, and addiction limit their usability for long-term chronic pain. The associated poor sleep pattern alters the circadian neurobiology, and further compromises the pain management. Here, we ai...