Adaptation of a RAS pathway activation signature from FF to FFPE tissues in colorectal cancer

Adaptation of a RAS pathway activation signature from FF to FFPE tissues in colorectal cancer

Abstract Background The KRAS gene is mutated in about 40 % of colorectal cancer (CRC) cases, which has been clinically validated as a predictive mutational marker of intrinsic resistance to anti-EGFR inhibitor (EGFRi) therapy. Since nearly 60 % of patients with a wild type KRAS fail to respond to EG...

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Bibliographic Details
Main Authors: Bernard Omolo (Author), Mingli Yang (Author), Fang Yin Lo (Author), Michael J. Schell (Author), Sharon Austin (Author), Kellie Howard (Author), Anup Madan (Author), Timothy J. Yeatman (Author)
Format: Book
Published: BMC, 2016-10-01T00:00:00Z.
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