Identification of compounds with anti-convulsant properties in a zebrafish model of epileptic seizures

• मुख्य लेखकों: Sarah Baxendale (लेखक), Celia J. Holdsworth (लेखक), Paola L. Meza Santoscoy (लेखक), Michael R. M. Harrison (लेखक), James Fox (लेखक), Caroline A. Parkin (लेखक), Philip W. Ingham (लेखक), Vincent T. Cunliffe (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: The Company of Biologists, 2012-11-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

SUMMARY The availability of animal models of epileptic seizures provides opportunities to identify novel anticonvulsants for the treatment of people with epilepsy. We found that exposure of 2-day-old zebrafish embryos to the convulsant agent pentylenetetrazole (PTZ) rapidly induces the expression of...