Identification of compounds with anti-convulsant properties in a zebrafish model of epileptic seizures

• Main Authors: Sarah Baxendale (Author), Celia J. Holdsworth (Author), Paola L. Meza Santoscoy (Author), Michael R. M. Harrison (Author), James Fox (Author), Caroline A. Parkin (Author), Philip W. Ingham (Author), Vincent T. Cunliffe (Author)
• Format: Book
• Published: The Company of Biologists, 2012-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY The availability of animal models of epileptic seizures provides opportunities to identify novel anticonvulsants for the treatment of people with epilepsy. We found that exposure of 2-day-old zebrafish embryos to the convulsant agent pentylenetetrazole (PTZ) rapidly induces the expression of...