Identification of compounds with anti-convulsant properties in a zebrafish model of epileptic seizures

• Κύριοι συγγραφείς: Sarah Baxendale (Συγγραφέας), Celia J. Holdsworth (Συγγραφέας), Paola L. Meza Santoscoy (Συγγραφέας), Michael R. M. Harrison (Συγγραφέας), James Fox (Συγγραφέας), Caroline A. Parkin (Συγγραφέας), Philip W. Ingham (Συγγραφέας), Vincent T. Cunliffe (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: The Company of Biologists, 2012-11-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

SUMMARY The availability of animal models of epileptic seizures provides opportunities to identify novel anticonvulsants for the treatment of people with epilepsy. We found that exposure of 2-day-old zebrafish embryos to the convulsant agent pentylenetetrazole (PTZ) rapidly induces the expression of...