NOX4 Mediates Epithelial Cell Death in Hyperoxic Acute Lung Injury Through Mitochondrial Reactive Oxygen Species

• Main Authors: Anantha Harijith (Author), Prathima Basa (Author), Alison Ha (Author), Jaya Thomas (Author), Anjum Jafri (Author), Panfeng Fu (Author), Peter M. MacFarlane (Author), Thomas M. Raffay (Author), Viswanathan Natarajan (Author), Tara Sudhadevi (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Management of acute respiratory distress involves O2 supplementation, which is lifesaving, but causes severe hyperoxic acute lung injury (HALI). NADPH oxidase (NOX) could be a major source of reactive oxygen species (ROS) in hyperoxia (HO). Epithelial cell death is a crucial step in the development...