Development of Novel Paclitaxel-Loaded ZIF-8 Metal-Organic Framework Nanoparticles Modified with Peptide Dimers and an Evaluation of Its Inhibitory Effect against Prostate Cancer Cells

• Main Authors: Heming Zhao (Author), Liming Gong (Author), Hao Wu (Author), Chao Liu (Author), Yanhong Liu (Author), Congcong Xiao (Author), Chenfei Liu (Author), Liqing Chen (Author), Mingji Jin (Author), Zhonggao Gao (Author), Youyan Guan (Author), Wei Huang (Author)
• Format: Book
• Published: MDPI AG, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Prostate cancer (PC) is one of the common malignant tumors of the male genitourinary system. Here, we constructed PTX@ZIF-8, which is a metal-organic-framework-encapsulated drug delivery nanoparticle with paclitaxel (PTX) as a model drug, and further modified the synthesized peptide dimer (Di-PEG<...