Cleavage of Occludin by Cigarette Smoke-Elicited Cathepsin S Increases Permeability of Lung Epithelial Cells

• Main Authors: Paul Bigot (Author), Simon Chesseron (Author), Ahlame Saidi (Author), Damien Sizaret (Author), Christelle Parent (Author), Agnès Petit-Courty (Author), Yves Courty (Author), Fabien Lecaille (Author), Gilles Lalmanach (Author)
• Format: Book
• Published: MDPI AG, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background. Chronic obstructive pulmonary disease (COPD) is an irreversible disease mainly caused by smoking. COPD is characterized by emphysema and chronic bronchitis associated with enhanced epithelial permeability. Hypothesis. Lung biopsies from smokers revealed a decreased expression level of oc...