Panax notoginseng saponins (PNS) attenuate Th17 cell differentiation in CIA mice via inhibition of nuclear PKM2-mediated STAT3 phosphorylation

• Main Authors: Mei-Yu Shen (Author), Yu-Xi Di (Author), Xiang Wang (Author), Feng-Xiang Tian (Author), Ming-Fei Zhang (Author), Fei-Ya Qian (Author), Bao-Ping Jiang (Author), Xue-Ping Zhou (Author), Ling-Ling Zhou (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

AbstractContext Rheumatoid arthritis (RA) is an autoimmune disease with aberrant Th17 cell differentiation. Panax notoginseng (Burk.) F. H. Chen (Araliaceae) saponins (PNS) have an anti-inflammatory effect and can suppress Th17 cell differentiation.Objective To investigate mechanisms of PNS on Th17...