Noninvasive Diagnosis of the Mitochondrial Function of Doxorubicin-Induced Cardiomyopathy Using In Vivo Dynamic Nuclear Polarization-Magnetic Resonance Imaging

• Main Authors: Yukie Mizuta (Author), Tomohiko Akahoshi (Author), Hinako Eto (Author), Fuminori Hyodo (Author), Masaharu Murata (Author), Kentaro Tokuda (Author), Masatoshi Eto (Author), Ken Yamaura (Author)
• Format: Book
• Published: MDPI AG, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Doxorubicin (DOX) induces dose-dependent cardiotoxicity via oxidative stress and abnormal mitochondrial function in the myocardium. Therefore, a noninvasive in vivo imaging procedure for monitoring the redox status of the heart may aid in monitoring diseases and developing treatments. However, an ap...