Aminobenzotriazole inhibits and induces several key drug metabolizing enzymes complicating its utility as a pan CYP inhibitor for reaction phenotyping

• 主要な著者: Krishna C. Aluri (著者), Marina Slavsky (著者), Ying Tan (著者), Andrea Whitcher‐Johnstone (著者), Zhoupeng Zhang (著者), Niresh Hariparsad (著者), Diane Ramsden (著者)
• フォーマット: 図書
• 出版事項: Wiley, 2024-03-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Abstract Aminobenzotriazole (ABT) is commonly used as a non‐selective inhibitor of cytochrome P450 (CYP) enzymes to assign contributions of CYP versus non‐CYP pathways to the metabolism of new chemical entities. Despite widespread use, a systematic review of the drug-drug interaction (DDI) potential...