Aminobenzotriazole inhibits and induces several key drug metabolizing enzymes complicating its utility as a pan CYP inhibitor for reaction phenotyping

• Main Authors: Krishna C. Aluri (Author), Marina Slavsky (Author), Ying Tan (Author), Andrea Whitcher‐Johnstone (Author), Zhoupeng Zhang (Author), Niresh Hariparsad (Author), Diane Ramsden (Author)
• Format: Book
• Published: Wiley, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Aminobenzotriazole (ABT) is commonly used as a non‐selective inhibitor of cytochrome P450 (CYP) enzymes to assign contributions of CYP versus non‐CYP pathways to the metabolism of new chemical entities. Despite widespread use, a systematic review of the drug-drug interaction (DDI) potential...