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Aminobenzotriazole inhibits and induces several key drug metabolizing enzymes complicating its utility as a pan CYP inhibitor for reaction phenotyping

Abstract Aminobenzotriazole (ABT) is commonly used as a non‐selective inhibitor of cytochrome P450 (CYP) enzymes to assign contributions of CYP versus non‐CYP pathways to the metabolism of new chemical entities. Despite widespread use, a systematic review of the drug-drug interaction (DDI) potential...

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Bibliographic Details
Main Authors: Krishna C. Aluri (Author), Marina Slavsky (Author), Ying Tan (Author), Andrea Whitcher‐Johnstone (Author), Zhoupeng Zhang (Author), Niresh Hariparsad (Author), Diane Ramsden (Author)
Format: Book
Published: Wiley, 2024-03-01T00:00:00Z.
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