Zebrafish enpp1 mutants exhibit pathological mineralization, mimicking features of generalized arterial calcification of infancy (GACI) and pseudoxanthoma elasticum (PXE)

• Main Authors: Alexander Apschner (Author), Leonie F. A. Huitema (Author), Bas Ponsioen (Author), Josi Peterson-Maduro (Author), Stefan Schulte-Merker (Author)
• Format: Book
• Published: The Company of Biologists, 2014-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In recent years it has become clear that, mechanistically, biomineralization is a process that has to be actively inhibited as a default state. This inhibition must be released in a rigidly controlled manner in order for mineralization to occur in skeletal elements and teeth. A central aspect of thi...