A New Crystal Form of the SARS-CoV-2 Receptor Binding Domain: CR3022 Complex-An Ideal Target for In-Crystal Fragment Screening of the ACE2 Binding Site Surface

• 主要な著者: Charlie Nichols (著者), Joseph Ng (著者), Annika Keshu (著者), Franca Fraternali (著者), Gian F. De Nicola (著者)
• フォーマット: 図書
• 出版事項: Frontiers Media S.A., 2020-12-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

In-crystal fragment screening is a powerful tool to chemically probe the surfaces used by proteins to interact, and identify the chemical space worth exploring to design protein-protein inhibitors. A crucial prerequisite is the identification of a crystal form where the target area is exposed and ac...