Bcl-XL but Not Bcl-2 Is a Potential Target in Medulloblastoma Therapy

• Main Authors: Mike-Andrew Westhoff (Author), Marie Schuler-Ortoli (Author), Daniela Zerrinius (Author), Amina Hadzalic (Author), Andrea Schuster (Author), Hannah Strobel (Author), Angelika Scheuerle (Author), Tiana Wong (Author), Christian Rainer Wirtz (Author), Klaus-Michael Debatin (Author), Aurelia Peraud (Author)
• Format: Book
• Published: MDPI AG, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Medulloblastoma (MB) is the most common solid tumour in children and, despite current treatment with a rather aggressive combination therapy, accounts for 10% of all deaths associated with paediatric cancer. Breaking the tumour cells' intrinsic resistance to therapy-induced cell death should le...