Sesquiterpene Lactones Attenuate Paclitaxel Resistance Via Inhibiting MALAT1/STAT3/ FUT4 Axis and P-Glycoprotein Transporters in Lung Cancer Cells

• Main Authors: Yaming Ding (Author), Zhang Zhen (Author), Muhammad Azhar Nisar (Author), Farman Ali (Author), Riaz Ud Din (Author), Muhammad Khan (Author), Tafail Akbar Mughal (Author), Gulzar Alam (Author), Linlin Liu (Author), Muhammad Zubair Saleem (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Paclitaxel resistance is a challenging factor in chemotherapy resulting in poor prognosis and cancer recurrence. Signal transducer and activator of transcription factor 3 (STAT3), a key transcription factor, performs a critical role in cancer development, cell survival and chemoresistance, while its...