Mutation of Mitochondrial DNA G13513A Presenting with Leigh Syndrome, Wolff-Parkinson-White Syndrome and Cardiomyopathy

• Main Authors: Shi-Bing Wang (Author), Wen-Chin Weng (Author), Ni-Chung Lee (Author), Wuh-Liang Hwu (Author), Pi-Chuan Fan (Author), Wang-Tso Lee (Author)
• Format: Book
• Published: Elsevier, 2008-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mutation of mitochondrial DNA (mtDNA) G13513A, encoding the ND5 subunit of respiratory chain complex I, can cause mitochondrial encephalopathy with lactic acidosis and stroke-like episodes (MELAS) and Leigh syndrome. Wolff-Parkinson-White (WPW) syndrome and optic atrophy were reported in a high prop...