Recent developments on PET radiotracers for TSPO and their applications in neuroimaging

• Main Authors: Lingling Zhang (Author), Kuan Hu (Author), Tuo Shao (Author), Lu Hou (Author), Shaojuan Zhang (Author), Weijian Ye (Author), Lee Josephson (Author), Jeffrey H. Meyer (Author), Ming-Rong Zhang (Author), Neil Vasdev (Author), Jinghao Wang (Author), Hao Xu (Author), Lu Wang (Author), Steven H. Liang (Author)
• Format: Book
• Published: Elsevier, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The 18 kDa translocator protein (TSPO), previously known as the peripheral benzodiazepine receptor, is predominately localized to the outer mitochondrial membrane in steroidogenic cells. Brain TSPO expression is relatively low under physiological conditions, but is upregulated in response to glial c...