Anti-Inflammatory Effects of RTD-1 in a Murine Model of Chronic <i>Pseudomonas aeruginosa</i> Lung Infection: Inhibition of NF-κB, Inflammasome Gene Expression, and Pro-IL-1β Biosynthesis

• Prif Awduron: Mansour A. Dughbaj (Awdur), Jordanna G. Jayne (Awdur), A Young J. Park (Awdur), Timothy J. Bensman (Awdur), Marquerita Algorri (Awdur), Andre J. Ouellette (Awdur), Michael E. Selsted (Awdur), Paul M. Beringer (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: MDPI AG, 2021-08-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Vicious cycles of chronic airway obstruction, lung infections with <i>Pseudomonas aeruginosa</i>, and neutrophil-dominated inflammation contribute to morbidity and mortality in cystic fibrosis (CF) patients. Rhesus theta defensin-1 (RTD-1) is an antimicrobial macrocyclic peptide with imm...