Anti-Inflammatory Effects of RTD-1 in a Murine Model of Chronic <i>Pseudomonas aeruginosa</i> Lung Infection: Inhibition of NF-κB, Inflammasome Gene Expression, and Pro-IL-1β Biosynthesis

Anti-Inflammatory Effects of RTD-1 in a Murine Model of Chronic <i>Pseudomonas aeruginosa</i> Lung Infection: Inhibition of NF-κB, Inflammasome Gene Expression, and Pro-IL-1β Biosynthesis

Vicious cycles of chronic airway obstruction, lung infections with <i>Pseudomonas aeruginosa</i>, and neutrophil-dominated inflammation contribute to morbidity and mortality in cystic fibrosis (CF) patients. Rhesus theta defensin-1 (RTD-1) is an antimicrobial macrocyclic peptide with imm...

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Main Authors: Mansour A. Dughbaj (Author), Jordanna G. Jayne (Author), A Young J. Park (Author), Timothy J. Bensman (Author), Marquerita Algorri (Author), Andre J. Ouellette (Author), Michael E. Selsted (Author), Paul M. Beringer (Author)
Format: Book
Published: MDPI AG, 2021-08-01T00:00:00Z.
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3rd Floor Main Library

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