Human STING Is Regulated by an Autoinhibitory Mechanism for Type I Interferon Production

• Main Authors: Shishi Qi (Author), Changwan Wang (Author), Rui Zhang (Author), Junyan Zhu (Author), Xianteng Hou (Author), Yingbo Jiang (Author), Jiaxin Li (Author), Miao Ren (Author), Muwang Li (Author), Fajian Hou (Author)
• Format: Book
• Published: Karger Publishers, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Stimulator of interferon genes (STING) plays a pivotal role in type I interferon-mediated innate immune response to the cytoplasmic detection of aberrant DNA. STING is a membrane protein localized in endoplasmic reticulum (ER), which upon stimulation translocates to Golgi apparatus and activates dow...