Activation of AMPK/SIRT1/FOXO3a signaling by BMS-477118 (saxagliptin) mitigates chronic colitis in rats: uncovering new anti-inflammatory and antifibrotic roles

• Main Authors: Elsayed A. Elmorsy (Author), Mahmoud E. Youssef (Author), Mohamed R. Abdel-Hamed (Author), Maha M. Amer (Author), Sahar R. Elghandour (Author), Abdullah S. Alkhamiss (Author), Nahla B. Mohamed (Author), Mostafa M. Khodeir (Author), Hossam A. Elsisi (Author), Thamir Saad Alsaeed (Author), Manal M. Kamal (Author), Abousree T. Ellethy (Author), Basem H. Elesawy (Author), Sameh Saber (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ulcerative colitis (UC) is a debilitating chronic disease marked by persistent inflammation and intestinal fibrosis. Despite the availability of various treatments, many patients fail to achieve long-term remission, underscoring a significant unmet therapeutic need. BMS-477118, a reversible inhibito...