Histone acetyltransferase P300 deficiency promotes ferroptosis of vascular smooth muscle cells by activating the HIF-1α/HMOX1 axis

• Main Authors: Juan Shi (Author), Qun-Hui Wang (Author), Xiang Wei (Author), Bo Huo (Author), Jian-Nan Ye (Author), Xin Yi (Author), Xin Feng (Author), Ze-Min Fang (Author), Ding-Sheng Jiang (Author), Ming-Jia Ma (Author)
• Format: Book
• Published: BMC, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background E1A-associated 300-kDa protein (P300), an endogenous histone acetyltransferase, contributes to modifications of the chromatin landscape of genes involved in multiple cardiovascular diseases. Ferroptosis of vascular smooth muscle cells (VSMCs) is a novel pathological mechanism of...