Single-cell, single-nucleus and xenium-based spatial transcriptomics analyses reveal inflammatory activation and altered cell interactions in the hippocampus in mice with temporal lobe epilepsy

• Main Authors: Quanlei Liu (Author), Chunhao Shen (Author), Yang Dai (Author), Ting Tang (Author), Changkai Hou (Author), Hongyi Yang (Author), Yihe Wang (Author), Jinkun Xu (Author), Yongchang Lu (Author), Yunming Wang (Author), Yongzhi Shan (Author), Penghu Wei (Author), Guoguang Zhao (Author)
• Format: Book
• Published: BMC, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Temporal lobe epilepsy (TLE) is among the most common types of epilepsy and often leads to cognitive, emotional, and psychiatric issues due to the frequent seizures. A notable pathological change related to TLE is hippocampal sclerosis (HS), which is characterized by neuronal los...