Salvianolic acid B protects against acetaminophen hepatotoxicity by inducing Nrf2 and phase II detoxification gene expression via activation of the PI3K and PKC signaling pathways

• मुख्य लेखकों: Musen Lin (लेखक), Xiaohan Zhai (लेखक), Guangzhi Wang (लेखक), Xiaofeng Tian (लेखक), Dongyan Gao (लेखक), Lei Shi (लेखक), Hang Wu (लेखक), Qing Fan (लेखक), Jinyong Peng (लेखक), Kexin Liu (लेखक), Jihong Yao (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2015-02-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Acetaminophen (APAP) is used drugs worldwide for treating pain and fever. However, APAP overdose is the principal cause of acute liver failure in Western countries. Salvianolic acid B (SalB), a major water-soluble compound extracted from Radix Salvia miltiorrhiza, has well-known antioxidant and anti...