Identification of Novel Loci Involved in Adalimumab Response in Crohn's Disease Patients Using Integration of Genome Profiling and Isoform-Level Immune-Cell Deconvoluted Transcriptome Profiling of Colon Tissue

• Auteurs principaux: Mario Gorenjak (Auteur), Gregor Jezernik (Auteur), Martina Krušič (Auteur), Pavel Skok (Auteur), Uroš Potočnik (Auteur)
• Format: Livre
• Publié: MDPI AG, 2022-09-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Crohn's disease is a consequence of dysregulated inflammatory response to the host's microbiota. Although anti-TNF treatment improves the quality of the patient's life, a large proportion of patients lose response to the treatment. The past decade of research has led to a continuum of...